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  • Biological Activity of Der p 1 and Der f 1 in Allergic Asthma and Their Contribution in Inflammation and the Role of Anti-inflammation in Allergic Asthma

    Asthma is a disease marked by chronic inflammation of the airways, with indications including wheezing, shortness of breath, and/or cough. As reported by GINA, the global prevalence of asthma is 1-18%. One type of...
    Julian Indonesia , Anna Rozaliyani Indonesia , Heri Wibowo Indonesia , Triya Damayanti Indonesia
    Pages: 560-573 2023-12-05
    10.24036/eksakta/vol23-iss04/463
    532 313
  • Pharmacophore Modeling, Molecular Docking, and ADMET Approach for Identification of Anti-Cancer Agents Targeting the C-Jun N-Terminal Kinase (JNK) Protein

    One of the most prevalent cancers in Indonesia is breast cancer, based on Indonesia's pathological-based registration.    Breast cancer is a complex, heterogeneous disease classified into...
    Nur Ayu Ramadanti Indonesia , Linda Erlina Indonesia , Rafika Indah Paramita Indonesia , Aryo Tedjo Indonesia , Fadillah Fadillah Indonesia , Surya Dwira Indonesia
    Pages: 99-111 2023-03-30
    10.24036/eksakta/vol24-iss01/391
    785 375
  • Identification of Antiviral Compounds against Hepatitis C Virus (HCV) targeting NS3 Protein by Pharmacophore Modeling, Molecular Docking, and ADMET Approach

    Hepatitis C Virus (HCV) is a world health problem. HCV infection is initiated by various structural and non-structural proteins. The HCV NS3 protein has an important function in viral replication. The N-terminal...
    Ratih Rahayu Indonesia , Linda Erlina Indonesia , Suratno Lulut Ratnoglik Indonesia , Andi Yasmon Indonesia , Fadilah Indonesia , Rafika Indah Paramita Indonesia
    Pages: 523-536 2023-12-30
    10.24036/eksakta/vol23-iss04/448
    489 275
  • Mediastinal Tumor Thymoma Type B1 T4N2M1B Stage IVB with Multimodality Therapy

    The incidence of thymoma increases with age, generally occurs in the 40-60s. Thymoma cases are rare at a young age. The prevalence of thymoma at a young age is very small at 0.6 – 5% of all thymoma cases. Thymoma...
    Muhammad Zakki Al-Fajri Indonesia , Sabrina Ermayanti Indonesia , Afriani Afriani Indonesia
    Pages: 42-54 2022-03-30
    10.24036/eksakta/vol23-iss01/300
    713 397
  • Gastrointestinal Dysfunction after Traumatic Brain Injury: Mechanisms Linking The Gut, Inflammation, and the HPA Axis

    Traumatic brain injury (TBI) is a major global health problem that often leads to systemic complications beyond neurological damage, notably gastrointestinal (GI) dysfunction. The mechanisms linking TBI to GI...
    Dwi Hastuti Indonesia , Sri Widia A Jusman Indonesia , Reni Paramita Indonesia
    Pages: 423-439 2025-12-30
    10.24036/eksakta/vol26-iss04/601
    183 161
  • Effects of Radiation on the Histology of the Tongue and Lip Mucosa in Rats : Preliminary Research

    The tongue and lip mucosa, as tissues with high cell proliferation rates, are highly susceptible to injury caused by ionizing radiation. This study aimed to evaluate histological changes in the tongue and lip mucosa...
    Sagita Yudha Indonesia , Aisyah Elliyanti Indonesia , Eti Yerizel Indonesia , Sukri Rahman Indonesia
    Pages: 374-381 2026-06-30
    10.24036/eksakta/vol27-iss03/696
    57 71
  • Molecular Insights into Acne Vulgaris: A Multi-Omics Approach Towards Precision Medicine

    Acne vulgaris is a common dermatological disorder that significantly impacts quality of life, yet its complex pathogenesis remains incompletely understood, contributing to the variability in clinical presentation and...
    Hartanti Dian Ikawati Indonesia , Fadilah Indonesia , Fitria Agustina Indonesia
    Pages: 371-383 2025-09-30
    10.24036/eksakta/vol26-iss03/591
    243 187
  • The Spectrum of Severity: Clinical and Hematological Markers in Jakarta’s COVID-19 Patients

    Jakarta, a densely populated megacity with high hybrid immunity, presents a unique epidemiological landscape for COVID-19. Understanding the clinical and hematological markers in this context is vital for improving...
    Erlin Listiyaningsih Indonesia , Shinta Dewi Permata Sari Indonesia , Dewi Martalena Indonesia , Wawang Sukarya Indonesia
    Pages: 182-190 2026-04-30
    10.24036/eksakta/vol27-iss02/660
    64 70
  • Ligand Based Pharmacophore Modelling, Virtual Screening, Molecular Docking, and ADMETOX of Natural Compounds as Antibiotic Candidates against Urinary Tract Infections (UTI)

    The use of antibiotic drugs requires close supervision that patients take antibiotics according to the rules. Irregular antibiotic use led to increased ADR cases (Antibiotic Drug-resistant). ADR is when an individual...
    Windy Dwininda Indonesia , Linda Erlina Indonesia , Rafika Indah Paramita Indonesia , Fadillah Fadillah Indonesia , Surya Dwira Indonesia , Jaka Fajar Fatriansyah Indonesia
    Pages: 193-206 2023-06-30
    10.24036/eksakta/vol24-iss02/404
    1250 350
  • Structure-Based Virtual Screening and Molecular Docking on the Indonesian Herbal Compound as a Promising Insulin Receptor (INSR) Inhibitor to Suppress Tumor Growth

    A healthy cell maintains a homeostasis condition of glucose level, whereas cancer cells do not. Increased glucose uptake is a hallmark of cancer cells that helps them survive, proliferate, and spread. INSR is one of...
    Veronica Hesti Candraningrum Indonesia , Linda Erlina Indonesia , Rafika Indah Paramita Indonesia , Fadillah Fadillah Indonesia , Surya Dwira Indonesia , Jaka Fajar Fatriansyah Indonesia
    Pages: 487-499 2023-12-30
    10.24036/eksakta/vol23-iss04/452
    533 338
  • Effect of Coriander (Coriandrum sativum Lour) Seed-Ethanol Extract on Spermatozoa Quality in Alloxan-Induced Male Rats

    Coriander fruit ( Coriandrum sativum Lour) has long been used and utilized by humans as a medicine to lower blood sugar levels. This study aimed to test the ethanol extract of coriander ( Coriandrum sativum Lour)...
    Irza Haicha Pratama Indonesia , Neka Cahyanda Putri Indonesia , Nuryani Nainggolan Indonesia , Ok Yurizal Indonesia
    Pages: 9-18 2023-03-30
    10.24036/eksakta/vol24-iss01/365
    330 265
  • In Silico Evaluation of Natural Compounds as Dual Inhibitors of Exotoxin A and LasB (Elastase) Virulence Proteins in Pseudomonas aeruginosa

    Pseudomonas aeruginosa is an opportunistic pathogen whose virulence is largely mediated by Exotoxin A and LasB (elastase), making them promising anti-virulence drug targets. This study aimed to evaluate the...
    Andrias Bayu Fariska Indonesia , Linda Erlina Indonesia , Ade Arsianti Indonesia , Aryo Tedjo Indonesia
    Pages: 480-499 2025-12-30
    10.24036/eksakta/vol26-iss04/631
    169 177
  • Molecular Simulation for Screening Bioactive Compounds as Potential Candidate for Alzheimer’s Disease

    Alzheimer’s disease is one of the neurodegenerative diseases that afflict the elderly. One of the symptoms is a loss cognitive ability due to neuronal death caused by amyloid plaque accumulation. Alzheimer’s...
    Immanuelle Kezia Indonesia , Linda Erlina Indonesia , Ninik Mudjihartini Indonesia , Fadilah Fadilah Indonesia
    Pages: 179-192 2023-06-30
    10.24036/eksakta/vol24-iss02/401
    626 474
  • Exploring the Chemopreventive Potential of Soybean Phytochemicals Targeting BRCA1 Protein: A Molecular Docking Study

    Breast cancer remains a significant cause of cancer-related mortality among women globally, highlighting the importance for preventive strategies targeting early molecular events. BRCA1 plays a critical role in...
    Regina Liviandari Indonesia , Ari Estuningtyas Indonesia , Kusmardi Indonesia , Linda Erlina Indonesia
    Pages: 191-206 2026-04-30
    10.24036/eksakta/vol27-iss02/671
    67 95
  • Molecular Docking of ftsZ Protein of Staphylococcus aureus to Indonesian Herbal Compound

    Microbial resistance to antibiotics is a growing global problem, and new antibacterial agents are needed to overcome this. One of the bacteria with a high level of resistance is Staphylococcus aureus . Herbal...
    Maria Diyan Monica Indonesia , Linda Erlina Indonesia , Fadilah Fadilah Indonesia , Rafika Indah Paramita Indonesia
    Pages: 1-13 2024-03-30
    10.24036/eksakta/vol25-iss01/431
    447 385
  • Identification of Active Compounds of Leaf Extract and Seed Oil of Moringa oleifera in TrkB Receptor as Neuroprotective by Molecular Docking

    The functional ability of the brain will decline progressively during aging which usually involves changes in plasticity. BDNF is one of the neurotrophins that regulates plasticity via TrkB receptors. So the...
    Muhamad Sadam Safutra Indonesia , Fadilah Indonesia , Wawaimuli Arozal Indonesia , Agian Jeffilano Barinda Indonesia
    Pages: 151-163 2024-06-30
    10.24036/eksakta/vol25-iss02/442
    304 309
  • Molecular Pathway of Phytochemicals in Preventing Sarcopenia

    Sarcopenia, the age-related decline in muscle mass and function, poses a significant global health challenge. This systematic review synthesizes evidence from preclinical studies published between 2020 and 2025 to...
    Desy Nofita Sari Indonesia , Roman Ardian Goenarjo Indonesia , Imelda Rosalyn Sianipar Indonesia
    Pages: 384-395 2025-09-30
    10.24036/eksakta/vol26-iss03/621
    212 239
  • Learning and Memory Impairment in High Fat Diet Induced Obesity

    Obesity is a manifestation of abnormal fat accumulation which can lead to impairment in several organs, including the brain. Neuroinflammation is considered the cause of cell death as well as reactive oxygen species...
    Citra Ariani Indonesia , Nurhadi Ibrahim Indonesia , Sophie Yolanda Indonesia
    Pages: 23-34 2025-03-30
    10.24036/eksakta/vol26-iss01/483
    150 263
  • Morphological Characteristics and Differentiation of Acinetobacter baumannii Colony on Selective Medium CHROMagar Acinetobacter

    Acinetobacter is an opportunistic pathogen that causes nosocomial infections and is one of the pathogens with the highest prevalence in the world. In addition to its prevalence, the number of isolates that are...
    Edy Wiranto Indonesia , Ariyani Kiranasari Indonesia , Lia Kusumawati Indonesia , Mutiara Indonesia , Tryna Tania Indonesia
    Pages: 91-98 2024-03-30
    10.24036/eksakta/vol25-iss01/482
    549 457
  • Nutraceutical Product Ice Cream from Dry Flower (Echinacea purpurea Lour) As an Immunomodulator in Pandemic Era: Ekino Ice

    Echinacea purpurea is a flower that is rich in its main antioxidant content comes from flavonoids, phenols, and cystic acids can be utilized as an immunomodulator during the Covid-19 pandemic. Ekinase flowers are...
    Reza Putri Oktavia Indonesia , Novia Vivin Safitri Indonesia , Nurus Samsiyah Indonesia , Salsabila Tri Rahmi Indonesia , Devi Purnamasari Indonesia
    Pages: 207-215 2023-06-30
    10.24036/eksakta/vol24-iss02/389
    504 428
  • Virtual Screening and Molecular Modelling Anticancer Molecules Targeting Fibroblast Growth Factor Receptor 4

    Cancer, characterized by uncontrolled cell proliferation, is a leading global cause of mortality. Targeting the fibroblast growth factor receptor (FGFR), a receptor tyrosine kinase (RTK), holds promise for anticancer...
    Feby Lilia Rosa Indonesia , Fadilah Fadilah Indonesia , Linda Erlina Indonesia
    Pages: 276-288 2024-09-04
    10.24036/eksakta/vol25-iss03/464
    305 271
  • Identification of Potential Biomarkers for Hypertensive Nephropathy by Bioinformatics Analysis

    Hypertensive nephropathy (HN) is a common complication of chronic hypertension that leads to kidney damage. This study aimed to identify potential biomarkers and key pathways associated with HN using bioinformatics...
    Ariski Fajarido Indonesia , Fadilah Fadilah Indonesia , Wawaimuli Arozal Indonesia
    Pages: 484-497 2024-12-30
    10.24036/eksakta/vol25-iss04/537
    202 225
  • Distribution of blaCTX-M, blaSHV, blaTEM genes in Extended Spectrum β-Laktamase Producing Klebsiella pneumoniae from Clinical Isolates in Jakarta

    Klebsiella pneumoniae is one of the ESKAPE pathogens ( Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa , and Enterobacter spp.) due to their...
    Yulia Engel Indonesia , Conny Riana Tjampakasari Indonesia , Fithriyah Sjatha Indonesia
    Pages: 175-185 2025-06-30
    10.24036/eksakta/vol26-iss02/549
    284 209
  • The Implementation of Machine Learning Algorithms for Breast Cancer Biomarker Validation in Metabolomics Studies

    Breast cancer is a heterogeneous disease characterized by distinct molecular and metabolic characteristics, making its diagnostics and treatment challenging. The existence of metabolic reprogramming in breast cancer...
    Nindhyana Diwaratri Ratnaningayu Indonesia , Aryo Tedjo Indonesia , Sonar Soni Panigoro Indonesia
    Pages: 468-483 2024-12-30
    10.24036/eksakta/vol25-iss04/553
    222 253
  • Community Attitude Toward The Behavior Of Reducing and Handling Plastic Waste In Water Sweet Beach Area, Padang City

    The aim of the study was to describe people's attitudes towards the behavior of reducing and handling plastic waste in the Air Manis Beach area of Padang City. This research method uses a qualitative approach in the...
    Rira Fauziah Hasibuan Indonesia , Nur Afrainin Syah Indonesia , Ida Rahmah Burhan Indonesia
    Pages: 87-101 2021-06-27
    10.24036/eksakta/vol22-iss2/256
    502 371
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