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Biological Activity of Der p 1 and Der f 1 in Allergic Asthma and Their Contribution in Inflammation and the Role of Anti-inflammation in Allergic Asthma
Asthma is a disease marked by chronic inflammation of the airways, with indications including wheezing, shortness of breath, and/or cough. As reported by GINA, the global prevalence of asthma is 1-18%. One type of... -
Pharmacophore Modeling, Molecular Docking, and ADMET Approach for Identification of Anti-Cancer Agents Targeting the C-Jun N-Terminal Kinase (JNK) Protein
One of the most prevalent cancers in Indonesia is breast cancer, based on Indonesia's pathological-based registration.   Breast cancer is a complex, heterogeneous disease classified into... -
Identification of Antiviral Compounds against Hepatitis C Virus (HCV) targeting NS3 Protein by Pharmacophore Modeling, Molecular Docking, and ADMET Approach
Hepatitis C Virus (HCV) is a world health problem. HCV infection is initiated by various structural and non-structural proteins. The HCV NS3 protein has an important function in viral replication. The N-terminal... -
Mediastinal Tumor Thymoma Type B1 T4N2M1B Stage IVB with Multimodality Therapy
The incidence of thymoma increases with age, generally occurs in the 40-60s. Thymoma cases are rare at a young age. The prevalence of thymoma at a young age is very small at 0.6 – 5% of all thymoma cases. Thymoma... -
Gastrointestinal Dysfunction after Traumatic Brain Injury: Mechanisms Linking The Gut, Inflammation, and the HPA Axis
Traumatic brain injury (TBI) is a major global health problem that often leads to systemic complications beyond neurological damage, notably gastrointestinal (GI) dysfunction. The mechanisms linking TBI to GI... -
Effects of Radiation on the Histology of the Tongue and Lip Mucosa in Rats : Preliminary Research
The tongue and lip mucosa, as tissues with high cell proliferation rates, are highly susceptible to injury caused by ionizing radiation. This study aimed to evaluate histological changes in the tongue and lip mucosa... -
Molecular Insights into Acne Vulgaris: A Multi-Omics Approach Towards Precision Medicine
Acne vulgaris is a common dermatological disorder that significantly impacts quality of life, yet its complex pathogenesis remains incompletely understood, contributing to the variability in clinical presentation and... -
The Spectrum of Severity: Clinical and Hematological Markers in Jakarta’s COVID-19 Patients
Jakarta, a densely populated megacity with high hybrid immunity, presents a unique epidemiological landscape for COVID-19. Understanding the clinical and hematological markers in this context is vital for improving... -
Ligand Based Pharmacophore Modelling, Virtual Screening, Molecular Docking, and ADMETOX of Natural Compounds as Antibiotic Candidates against Urinary Tract Infections (UTI)
The use of antibiotic drugs requires close supervision that patients take antibiotics according to the rules. Irregular antibiotic use led to increased ADR cases (Antibiotic Drug-resistant). ADR is when an individual... -
Structure-Based Virtual Screening and Molecular Docking on the Indonesian Herbal Compound as a Promising Insulin Receptor (INSR) Inhibitor to Suppress Tumor Growth
A healthy cell maintains a homeostasis condition of glucose level, whereas cancer cells do not. Increased glucose uptake is a hallmark of cancer cells that helps them survive, proliferate, and spread. INSR is one of... -
Effect of Coriander (Coriandrum sativum Lour) Seed-Ethanol Extract on Spermatozoa Quality in Alloxan-Induced Male Rats
Coriander fruit ( Coriandrum sativum Lour) has long been used and utilized by humans as a medicine to lower blood sugar levels. This study aimed to test the ethanol extract of coriander ( Coriandrum sativum Lour)... -
In Silico Evaluation of Natural Compounds as Dual Inhibitors of Exotoxin A and LasB (Elastase) Virulence Proteins in Pseudomonas aeruginosa
Pseudomonas aeruginosa is an opportunistic pathogen whose virulence is largely mediated by Exotoxin A and LasB (elastase), making them promising anti-virulence drug targets. This study aimed to evaluate the... -
Molecular Simulation for Screening Bioactive Compounds as Potential Candidate for Alzheimer’s Disease
Alzheimer’s disease is one of the neurodegenerative diseases that afflict the elderly. One of the symptoms is a loss cognitive ability due to neuronal death caused by amyloid plaque accumulation. Alzheimer’s... -
Exploring the Chemopreventive Potential of Soybean Phytochemicals Targeting BRCA1 Protein: A Molecular Docking Study
Breast cancer remains a significant cause of cancer-related mortality among women globally, highlighting the importance for preventive strategies targeting early molecular events. BRCA1 plays a critical role in... -
Molecular Docking of ftsZ Protein of Staphylococcus aureus to Indonesian Herbal Compound
Microbial resistance to antibiotics is a growing global problem, and new antibacterial agents are needed to overcome this. One of the bacteria with a high level of resistance is Staphylococcus aureus . Herbal... -
Identification of Active Compounds of Leaf Extract and Seed Oil of Moringa oleifera in TrkB Receptor as Neuroprotective by Molecular Docking
The functional ability of the brain will decline progressively during aging which usually involves changes in plasticity. BDNF is one of the neurotrophins that regulates plasticity via TrkB receptors. So the... -
Molecular Pathway of Phytochemicals in Preventing Sarcopenia
Sarcopenia, the age-related decline in muscle mass and function, poses a significant global health challenge. This systematic review synthesizes evidence from preclinical studies published between 2020 and 2025 to... -
Learning and Memory Impairment in High Fat Diet Induced Obesity
Obesity is a manifestation of abnormal fat accumulation which can lead to impairment in several organs, including the brain. Neuroinflammation is considered the cause of cell death as well as reactive oxygen species... -
Morphological Characteristics and Differentiation of Acinetobacter baumannii Colony on Selective Medium CHROMagar Acinetobacter
Acinetobacter is an opportunistic pathogen that causes nosocomial infections and is one of the pathogens with the highest prevalence in the world. In addition to its prevalence, the number of isolates that are... -
Nutraceutical Product Ice Cream from Dry Flower (Echinacea purpurea Lour) As an Immunomodulator in Pandemic Era: Ekino Ice
Echinacea purpurea is a flower that is rich in its main antioxidant content comes from flavonoids, phenols, and cystic acids can be utilized as an immunomodulator during the Covid-19 pandemic. Ekinase flowers are... -
Virtual Screening and Molecular Modelling Anticancer Molecules Targeting Fibroblast Growth Factor Receptor 4
Cancer, characterized by uncontrolled cell proliferation, is a leading global cause of mortality. Targeting the fibroblast growth factor receptor (FGFR), a receptor tyrosine kinase (RTK), holds promise for anticancer... -
Identification of Potential Biomarkers for Hypertensive Nephropathy by Bioinformatics Analysis
Hypertensive nephropathy (HN) is a common complication of chronic hypertension that leads to kidney damage. This study aimed to identify potential biomarkers and key pathways associated with HN using bioinformatics... -
Distribution of blaCTX-M, blaSHV, blaTEM genes in Extended Spectrum β-Laktamase Producing Klebsiella pneumoniae from Clinical Isolates in Jakarta
Klebsiella pneumoniae is one of the ESKAPE pathogens ( Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa , and Enterobacter spp.) due to their... -
The Implementation of Machine Learning Algorithms for Breast Cancer Biomarker Validation in Metabolomics Studies
Breast cancer is a heterogeneous disease characterized by distinct molecular and metabolic characteristics, making its diagnostics and treatment challenging. The existence of metabolic reprogramming in breast cancer... -
Community Attitude Toward The Behavior Of Reducing and Handling Plastic Waste In Water Sweet Beach Area, Padang City
The aim of the study was to describe people's attitudes towards the behavior of reducing and handling plastic waste in the Air Manis Beach area of Padang City. This research method uses a qualitative approach in the...