EKSAKTA: Berkala Ilmiah Bidang MIPA
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Biological Activity of Der p 1 and Der f 1 in Allergic Asthma and Their Contribution in Inflammation and the Role of Anti-inflammation in Allergic Asthma

1 Master's Programme in Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
2 Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
3 Departement of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
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Abstract

Asthma is a disease marked by chronic inflammation of the airways, with indications including wheezing, shortness of breath, and/or cough. As reported by GINA, the global prevalence of asthma is 1-18%. One type of asthma is Allergic asthma which is triggered by allergens, like Der p 1 and Der f 1 which upregulate type II immune response to secret IL-4 and IL-13 to upregulate IgE secretion. IgE binds to FcεRI in mast cells to release mediators that cause hypercontraction, this condition leads to asthma. Meanwhile, anti-inflammatory IL-10 manages IgE production by reducing inflammatory cytokine production and changing isotype switching. IgE Production is a crucial step. Therefore, it is essential to explore the cellular and molecular factors that trigger the regulated isotype-switching IgE and its suppressed mechanism, so this review will explore the biological activity of Der p 1 and Der f I and their contribution to inflammation and the role of anti-inflammation in allergic asthma especially isotype switching IgE We used PRISMA approaches, and tools (RSCB PDB, Uniprot, and SMART). The result appeared Der p 1, and Der f 1 activity have impacts on IL-4, IL-13, IL-10, and IgE secretion.

Author Biographies

A

Anna Rozaliyani

Indonesia
Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia

1. Master's Programme in Biomedical Science, Faculty of  Medicine, Universitas Indonesia, Jakarta, Indonesia

2. Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia

H

Heri Wibowo

Indonesia
Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia

1. Master's Programme in Biomedical Science, Faculty of  Medicine, Universitas Indonesia, Jakarta, Indonesia

2. Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia

T

Triya Damayanti

Indonesia
Departement of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia

Departement of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia

References

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How to Cite

1.
Biological Activity of Der p 1 and Der f 1 in Allergic Asthma and Their Contribution in Inflammation and the Role of Anti-inflammation in Allergic Asthma. EKSAKTA [Internet]. 2023 Dec. 5 [cited 2026 Sep. 8];24(04):560-73. Available from: https://eksakta.ppj.unp.ac.id/index.php/eksakta/article/view/463