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Aug 28, 2023
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Nov 7, 2023
Published
Dec 5, 2023
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Abstract

Asthma is a disease marked by chronic inflammation of the airways, with indications including wheezing, shortness of breath, and/or cough. As reported by GINA, the global prevalence of asthma is 1-18%. One type of asthma is Allergic asthma which is triggered by allergens, like Der p 1 and Der f 1 which upregulate type II immune response to secret IL-4 and IL-13 to upregulate IgE secretion. IgE binds to FcεRI in mast cells to release mediators that cause hypercontraction, this condition leads to asthma. Meanwhile, anti-inflammatory IL-10 manages IgE production by reducing inflammatory cytokine production and changing isotype switching. IgE Production is a crucial step. Therefore, it is essential to explore the cellular and molecular factors that trigger the regulated isotype-switching IgE and its suppressed mechanism, so this review will explore the biological activity of Der p 1 and Der f I and their contribution to inflammation and the role of anti-inflammation in allergic asthma especially isotype switching IgE We used PRISMA approaches, and tools (RSCB PDB, Uniprot, and SMART). The result appeared Der p 1, and Der f 1 activity have impacts on IL-4, IL-13, IL-10, and IgE secretion.

Keywords

Allergy asthma, isotype switching, IgE, IL-4, IL-13, and IL-10

Article Details

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Author Biographies

Anna Rozaliyani, Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia

1. Master's Programme in Biomedical Science, Faculty of  Medicine, Universitas Indonesia, Jakarta, Indonesia

2. Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia

Heri Wibowo, Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia

1. Master's Programme in Biomedical Science, Faculty of  Medicine, Universitas Indonesia, Jakarta, Indonesia

2. Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia

Triya Damayanti, Departement of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia

Departement of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia

How to Cite
1.
Julian, Rozaliyani A, Wibowo H, Damayanti T. Biological Activity of Der p 1 and Der f 1 in Allergic Asthma and Their Contribution in Inflammation and the Role of Anti-inflammation in Allergic Asthma. EKSAKTA [Internet]. 2023Dec.5 [cited 2025Apr.26];24(04):560-73. Available from: https://eksakta.ppj.unp.ac.id/index.php/eksakta/article/view/463

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