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In Silico Evaluation of Bisbenzylisoquinoline Compounds from Stephania sp. as EGFR Inhibitors for Triple-Negative Breast Cancer
Triple-negative breast cancer (TNBC) represents a highly aggressive breast malignancy subtype characterized by constrained therapeutic alternatives and poor clinical outcomes. Since Epidermal Growth Factor Receptor...Amanda Triastuti Amanda
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Denny Satria
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In Silico Evaluation of Quinoline Derivatives as PfLDH Inhibitors through Molecular Docking, Lipinski’s Rule, and ADMET Profiling
This study aimed to evaluate quinoline-spiro derivatives as potential inhibitors of P. falciparum lactate dehydrogenase (PfLDH), a key enzyme involved in parasite energy metabolism, using an in silico approach....Livia Putrima Rijas
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Rahadian Zainul
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Meksim Rebezov
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Vikash Jakhmola
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Tarek Elkhooly
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In Silico Study of the Potential of Bioactive Compounds of Theobroma cacao as Antigingivitis Agents
This in silico study evaluated the antigingivitis potential of bioactive compounds from Theobroma cacao against matrix metalloproteinase-8 (MMP-8) (PDB ID: 5T35) using molecular docking and ADMET prediction....Amalia Putri Lubis
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Hidayanti Hidayanti
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Rahadian Zainul
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Iffat Syafiqoh Afif
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Siti Amiroch
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Mohammad Jamhuri
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Mohammad Hamim Zajuli Al Faroby
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In Silico Study Potential Secondary Metabolite Candidate of Citronella Grass (Cymbopogon nardus) on Immunity Cases
Foreign invaders in the form of bacteria, fungi, or viruses can cause various diseases if they enter the body, both molecularly and cellularly. Hence, the body needs a compound that can maintain and enhance the...Adella Infia Helga Veda
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M. Artabah Muchlisin
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Ahmad Shobrun Jamil
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Irsan Fahmi Almutahrihan
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Herland Satriawan
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In Silico Evaluation of Cardiac Glycosides from Vernonia amygdalina as EGFR Inhibitors in Triple Negative Breast Cancer
Triple-negative breast cancer (TNBC) is an aggressive subtype with limited targeted therapies, emphasizing the urgent need for novel molecular inhibitors. Epidermal growth factor receptor (EGFR) is overexpressed in...Gisela Agustin Habayahan
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Denny Satria
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Ligand Based Pharmacophore Modelling, Virtual Screening, Molecular Docking, and ADMETOX of Natural Compounds as Antibiotic Candidates against Urinary Tract Infections (UTI)
The use of antibiotic drugs requires close supervision that patients take antibiotics according to the rules. Irregular antibiotic use led to increased ADR cases (Antibiotic Drug-resistant). ADR is when an individual...Windy Dwininda
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Linda Erlina
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Rafika Indah Paramita
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Fadillah Fadillah
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Surya Dwira
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Jaka Fajar Fatriansyah
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Exploring the Chemopreventive Potential of Soybean Phytochemicals Targeting BRCA1 Protein: A Molecular Docking Study
Breast cancer remains a significant cause of cancer-related mortality among women globally, highlighting the importance for preventive strategies targeting early molecular events. BRCA1 plays a critical role in...Regina Liviandari
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Ari Estuningtyas
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Kusmardi
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Linda Erlina
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Potential Hydrophobic Pocket of Squalene Synthase: An In Silico Analysis
Cardiovascular disease cases increase due to consumption cholesterol dietary habit. It is well-known that squalence synthase (SQS) is the first committed enzyme for cholesterol synthesis. Therefore, SQS become target...Fitri Amelia
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Basultan Hidayat
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Iryani Iryani
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Iswendi Iswendi
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In Silico Evaluation of Natural Compounds as Dual Inhibitors of Exotoxin A and LasB (Elastase) Virulence Proteins in Pseudomonas aeruginosa
Pseudomonas aeruginosa is an opportunistic pathogen whose virulence is largely mediated by Exotoxin A and LasB (elastase), making them promising anti-virulence drug targets. This study aimed to evaluate the...Andrias Bayu Fariska
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Linda Erlina
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Ade Arsianti
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Aryo Tedjo
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Genome-Wide Association Study for the Identification of Genetic Variants Associated with Facial Skin Phenotypes
Facial skin phenotypes such as pigmentation, wrinkles, and lentigines are determined by genetics and environmental factors. The genetic factor is known as the basic formation of facial skin phenotype variations in...Rusma Yulita
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Yulia Ariani Aswin
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Rafika Indah Paramita
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The Potential of Active Compounds from Melinjo Leaves (Gnetum gnemon) as an Antihistamine using Molecular Docking Approach for Acetylcholine Muscarinic M3 Receptor Inhibition
Melinjo leaves (Gnetum gnemon) have been used traditionally in Maluku to treat spoilage in the fish product. Melinjo leaves contain secondary metabolites with anti-inflammatory and antibacterial biological...Nelson Gaspersz
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Matthew Adi Honey Amos
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Yusthinus T. Male
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Muh. Daswar A. Baharudin
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Dean Y.E. Leuwol
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Rahma El
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Priska M. Pattiasina
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Mario R. Sohilait
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Herland Satriawan
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The Implementation of Machine Learning Algorithms for Breast Cancer Biomarker Validation in Metabolomics Studies
Breast cancer is a heterogeneous disease characterized by distinct molecular and metabolic characteristics, making its diagnostics and treatment challenging. The existence of metabolic reprogramming in breast cancer...Nindhyana Diwaratri Ratnaningayu
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Aryo Tedjo
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Sonar Soni Panigoro
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Integrative Transcriptomic and Docking Analysis of Coffee Bioactives Targeting CCNA2, AKT1, and CDK2 in TNBC
Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype characterized by high proliferation rates, poor prognosis, and limited therapeutic options. Coffee-derived bioactive compounds have...Ida Neni Haryanti
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Linda Erlina
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Ade Arsianti
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Aryo Tedjo