Flavonoid Role as Autophagy Modulators in Breast Cancer Treatment Strategy

Frans Dany; Ade Arsianti; Linda Erlina; Ratih Rinendyaputri

doi:10.24036/eksakta/vol26-iss04/624

EKSAKTA: Berkala Ilmiah Bidang MIPA

Open Access

Flavonoid Role as Autophagy Modulators in Breast Cancer Treatment Strategy

Frans Dany ¹

, Ade Arsianti ¹

, Linda Erlina ¹

, Ratih Rinendyaputri ²

¹ Master’s Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia

² Center for Biomedical Research, National Research and Innovation Agency (BRIN), Cibinong, Indonesia

Published 2025-12-30

Vol. 26 No. 04 (2025) PAGES 440-455

DOI 10.24036/eksakta/vol26-iss04/624

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Abstract

Autophagy is a tightly regulated catabolic process that enables cancer cells to survive under metabolic stress and contributes to the development of chemoresistance. Targeting autophagy has therefore emerged as a promising strategy to enhance cancer therapy efficacy. Flavonoids, a diverse class of polyphenolic compounds abundantly found in plants, have gained considerable attention due to their broad-spectrum biological activities, including anticancer effects. Recent studies highlight their ability to modulate key signaling pathways involved in cell proliferation, apoptosis, and autophagy. Several flavonoids, such as fisetin, apigenin, and quercetin, exhibit roles as autophagy modulators depending on the cellular context, offering therapeutic flexibility. Their low toxicity and synergistic potential with conventional drugs underscore their relevance as adjuvant agents. This review discusses the critical role of autophagy in cancer progression and drug resistance, and examines current evidence supporting the integration of flavonoids as autophagy modulators in the design of more effective and targeted anticancer strategies, particularly in breast cancer therapy.

Author Biographies

A

Ade Arsianti

Master’s Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia

arsi_ade2002@yahoo.com

Department of Medical Chemistry

L

Linda Erlina

Master’s Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia

lindaerlina22@gmail.com

Department of Medical Chemistry

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Flavonoid Role as Autophagy Modulators in Breast Cancer Treatment Strategy

Abstract

Author Biographies

Ade Arsianti

Linda Erlina

References

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Flavonoid Role as Autophagy Modulators in Breast Cancer Treatment Strategy

Abstract

Author Biographies

Ade Arsianti

Linda Erlina

References

How to Cite

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