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Serological and Non-Sputum Biomarkers for Tuberculosis Diagnosis: A Systematic Review of Host- and Pathogen-Derived Signatures
Tuberculosis (TB) remains a major global health concern, with more than 10 million new cases reported annually. Conventional sputum-based diagnostics such as microscopy, culture, and GeneXpert MTB/RIF show limited... -
Identification of Potential Biomarkers for Hypertensive Nephropathy by Bioinformatics Analysis
Hypertensive nephropathy (HN) is a common complication of chronic hypertension that leads to kidney damage. This study aimed to identify potential biomarkers and key pathways associated with HN using bioinformatics... -
Molecular Insights into Acne Vulgaris: A Multi-Omics Approach Towards Precision Medicine
Acne vulgaris is a common dermatological disorder that significantly impacts quality of life, yet its complex pathogenesis remains incompletely understood, contributing to the variability in clinical presentation and... -
The Implementation of Machine Learning Algorithms for Breast Cancer Biomarker Validation in Metabolomics Studies
Breast cancer is a heterogeneous disease characterized by distinct molecular and metabolic characteristics, making its diagnostics and treatment challenging. The existence of metabolic reprogramming in breast cancer... -
Integrative Transcriptomic and Docking Analysis of Coffee Bioactives Targeting CCNA2, AKT1, and CDK2 in TNBC
Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype characterized by high proliferation rates, poor prognosis, and limited therapeutic options. Coffee-derived bioactive compounds have...