Role of Interleukin-10 Promoter Gene Polymorphisms in Susceptibility to Systemic Lupus Erythematosus: Systematic Review

Desi Oktariana; Ade Rizki Putri Ratih; Phey Liana; Kemas Ya’kub Rahadiyanto; Ririn Eviningtyas; Gita Dwi Prasasty; Yuniza Yuniza; Hafizzanovian Hafizzanovian; Aseptianova Aseptianova

doi:10.24036/eksakta/vol27-iss04/725

EKSAKTA: Berkala Ilmiah Bidang MIPA

Open Access

Role of Interleukin-10 Promoter Gene Polymorphisms in Susceptibility to Systemic Lupus Erythematosus: Systematic Review

Desi Oktariana ¹

, Ade Rizki Putri Ratih ²

, Phey Liana ¹

, Kemas Ya’kub Rahadiyanto ¹

, Ririn Eviningtyas ¹

, Gita Dwi Prasasty ³

, Yuniza Yuniza ⁴

, Hafizzanovian Hafizzanovian ⁴

, Aseptianova Aseptianova ⁵

¹ Department of Clinical Pathology, Department of Biomedical Science, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia

² Master of Biomedical Science Program, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia

³ Department of Parasitology, Department of Biomedical Science, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia

⁴ Department of Internal Medicine, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia

⁵ Department of Biology Education, Faculty of Teacher Training and Education, Universitas Muhammadiyah Palembang, Palembang, Indonesia

Published 2026-08-23

Vol. 27 No. 04 (2026) PAGES 659-669

DOI 10.24036/eksakta/vol27-iss04/725

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Abstract

Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease characterized by multisystem inflammation that predominantly affects women of reproductive age. Genetic factors, particularly polymorphisms within the interleukin-10 (IL-10) promoter region, have been implicated in disease susceptibility through their influence on cytokine expression and immune regulation. This systematic review aimed to evaluate the association between IL-10 promoter polymorphisms and SLE susceptibility across different populations. A systematic literature search was conducted according to PRISMA guidelines using Google Scholar, PubMed, ScienceDirect, SagePub, and Wiley Online Library for studies published between 2005 and 2025. Eligible case-control studies investigating IL-10 promoter polymorphisms in SLE were included. Of 82 records identified, 12 studies met the eligibility criteria, comprising 2,462 patients with SLE and 3,274 healthy controls. Most studies reported significant associations between SLE susceptibility and the IL-10 promoter polymorphisms −1082A/G, −819C/T, and −592C/A. The GCC haplotype was the most consistently reported risk haplotype and was frequently associated with increased IL-10 expression and greater susceptibility to SLE. Overall, current evidence supports the contribution of IL-10 promoter polymorphisms to genetic susceptibility to SLE across diverse populations.

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Role of Interleukin-10 Promoter Gene Polymorphisms in Susceptibility to Systemic Lupus Erythematosus: Systematic Review

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