Mobile Genetic Elements Contributing to Carbapenem Resistance in Acinetobacter baumannii: Current Insights

Azzahrah Khairunnisa Mardhiyah; Yulia Rosa Saharman; Fithriyah Sjatha

doi:10.24036/eksakta/vol25-iss04/534

EKSAKTA: Berkala Ilmiah Bidang MIPA

Open Access

Mobile Genetic Elements Contributing to Carbapenem Resistance in Acinetobacter baumannii: Current Insights

Azzahrah Khairunnisa Mardhiyah ¹

, Yulia ²

, Fithriyah ²

¹ Masterâ€™s Programme in Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia

² Department of Microbiology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia

Published 2024-12-30

Vol. 25 No. 04 (2024) PAGES 382-398

DOI 10.24036/eksakta/vol25-iss04/534

Views / Downloads 256 231

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Abstract

Acinetobacter baumannii has become a major cause of hospital-acquired infections with the rapid development of resistance to multiple antibiotics, including critical carbapenems. This resistance challenge limits treatment options and increases morbidity and mortality. The genetic plasticity of A. baumannii facilitates the mobilization of resistance genes via mobile genetic elements (MGE). Addressing this crisis requires a deeper understanding of the mechanisms by which MGE propagates carbapenem resistance. This paper provides a solution by systematically reviewing recent research on the role of MGE in disseminating resistance genes. Following PRISMA guidelines, a comprehensive literature review was conducted across various databases. The review revealed that resistance mechanisms primarily involve carbapenem-hydrolyzing enzymes and MGE, such as integrons, transposons, insertion sequences, and plasmids. Notably, genes like bla_OXA-23and bla_NDM are frequently mobilized by these elements, facilitating horizontal gene transfer and persistence. Understanding the mechanisms of MGE-mediated gene transfer is crucial for developing strategies to control the spread of antibiotic resistance inÂ A. baumannii.

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Mobile Genetic Elements Contributing to Carbapenem Resistance in Acinetobacter baumannii: Current Insights

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Mobile Genetic Elements Contributing to Carbapenem Resistance in Acinetobacter baumannii: Current Insights

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