EKSAKTA: Berkala Ilmiah Bidang MIPA
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Preventive Effect of Exercise on Kidney Fibrotic Pathway in Hypertension

1 Master’s Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
2 Department of Medical Physiology and Biophysics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
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Abstract

Uncontrolled hypertension can progress to kidney damage characterized by structural and functional changes, ultimately contributing to kidney fibrosis. Although, hypertension can be treated. However, the prevalence of hypertension in Indonesia is increasing. Therefore, proper treatment is necessary. Elevated levels of Transforming Growth Factor-β1 and Connective Tissue Growth Factor are critical factors that are key drivers of fibrogenic pathway. Appropriate exercise can control blood pressure, renal function, and prevent kidney fibrosis due to hypertension by activating the nitric oxide signaling pathway and reducing the regulation of the TGF-β, p-Smad2/3 and CTGF. This study aims to determine the optimal type of exercise to prevent kidney fibrosis caused by hypertension. Articles used are limited to the publication year between 2018 and 2024. We analyzed the role of exercise on kidney fibrotic pathway in hypertension using PRISMA methods from PubMed, ScienceDirect, Scopus, and Google Scholar. We found 7 articles and proved several significant effects of exercise on hypertension subjects. This study summarized that moderate-intensity exercise is more influential in controlling blood pressure and renal function, as well as inhibits kidney fibrosis due to hypertension.

References

1
World Health Organization. (2023). Global report on hypertension: The race against a silent killer. Geneva, Switzerland: World Health Organization. Retrieved from https://www.who.int/publications/i/item/9789240081062. Diakses pada tanggal 23 Juli 2024
2
KEMENKES RI. (2018). Laporan Hipertensi Riset Kesehatan Dasar (RISKESDAS). Badan Penelitian Dan Pengembangan Kesehatan. Retrieved from https://www.kemkes.go.id. Diakses pada tanggal 23 Juli 2024
3
Drożdż, D., Drożdż, M., & Wójcik, M. (2023). Endothelial dysfunction as a factor leading to arterial hypertension. Pediatric Nephrology (Berlin, Germany), 38(9), 2973–2985.
4
Huang, C., Lin, Y.Y., Yang, A.L., Kuo, T.W., Kuo, C.H., & Lee, S.D. (2018). Anti-Renal Fibrotic Effect of Exercise Training in Hypertension. International Journal of Molecular Sciences, 19(2).
5
Ameer, O. Z. (2022). Hypertension in chronic kidney disease: What lies behind the scene. Frontiers in Pharmacology, 13, 949260.
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How to Cite

1.
Preventive Effect of Exercise on Kidney Fibrotic Pathway in Hypertension . EKSAKTA [Internet]. 2024 Sep. 30 [cited 2026 Sep. 15];25(03):323-3. Available from: https://eksakta.ppj.unp.ac.id/index.php/eksakta/article/view/532

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