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Identification of Atherosclerosis Based on The Differences in Cholesterol and Creatinine in Indonesia with Multivariate Analysis of Variance

1 Student of The Applied Statistics Study Program, Faculty of Mathematics and Natural Science (FMIPA), Institut Pertanian Bogor, Bogor, Indonesia
2 Department of Statistics, Faculty of Mathematics and Natural Science (FMIPA), Institut Pertanian Bogor, Bogor, Indonesia
3 Health Research Organization, National Research, and Innovation Agency (BRIN), Bogor, Indonesia
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Abstract

Atherosclerosis is a chronic inflammatory disease indicated by plaque build-up in the arteries due to increased total cholesterol, low-density lipoproteins (LDL), triglycerides, and decreased high-density lipoproteins (HDL). It is also associated with disruption of renal function high creatinine blood level. This study aims to identify atherosclerosis based on differences in total cholesterol, HDL, LDL, triglycerides, and creatinine levels in 35.509 residents from 33 provinces and rural-urban areas in Indonesia. This study uses two-factor MANOVA where the province and rural-urban are the factors, followed by ANOVA and Tukey's test. Results show differences between total cholesterol, HDL, LDL, triglyceride, and creatinine levels of the residents among provinces and rural-urban areas. The Residents from Bangka Belitung and North Sulawesi provinces have the highest risk of atherosclerosis, and Jambi province has the most balanced condition. Urban residents tend to be at risk for atherosclerosis due to high levels of LDL, while rural residents are at risk by low HDL or high creatinine levels

References

1
P. Boucher, R. L. Matz, and J. Terrand. (2020). Atherosclerosis: Gone with the Wnt?. Atherosclerosis, vol. 301, pp. 15–22.
2
F. Schill, M. Persson, G. Engström, O. Melander, and S. Enhörning. (2021). Copeptin as a marker of atherosclerosis and arteriosclerosis. Atherosclerosis, vol. 338, pp. 64–68.
3
W. Li et al.. (2023). Spatial metabolomics identifies lipid profiles of human carotid atherosclerosis. Atherosclerosis, vol. 364, pp. 20–28.
4
K. R. Bainey et al.. (2019). The Burden of Atherosclerotic Cardiovascular Disease in South Asians Residing in Canada: A Reflection From the South Asian Heart Alliance. CJC Open, vol. 1, no. 6, pp. 271–281.
5
J.-J. Li et al.. (2020). Tackling cardiometabolic risk in the Asia Pacific region. Am. J. Prev. Cardiol., vol. 4, p. 100096.
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How to Cite

1.
Identification of Atherosclerosis Based on The Differences in Cholesterol and Creatinine in Indonesia with Multivariate Analysis of Variance. EKSAKTA [Internet]. 2023 Sep. 30 [cited 2026 Aug. 23];24(03):315-29. Available from: https://eksakta.ppj.unp.ac.id/index.php/eksakta/article/view/417