Main Article Content

Abstract

The digital era has brought many changes, both positive and negative impacts. The challenges of this digital era cover various sectors, including the health sector. One of the effects is the radiation from electromagnetic waves due to the use of cell phones that can interfere with health in the long term, such as a decrease in the immune system. This study aims to determine the secondary metabolite content of shallot peel extract and the formulation of the snack bar as a nutraceutical product with antioxidant properties. It becomes a solution to increase the immune system or immunomodulator. An evidenced by the phytochemical screening test, which gave positive results. In addition, this snack bar also positively contains essential nutrients, such as carbohydrates, protein, and fat. From the hedonic test, the snack bar formulation has the appearance of a snack bar in general, with solid consistency and brownish-yellow color, a characteristic odor of wheat, and a savory taste with a small amount of sweetness. This snack bar formulation has the potential as an immunomodulator against the decline in the immune system. The tastes of the snack bar are acceptable to the public.

Keywords

Nutraceutical Snack Bar Immunomodulator Shallot Peel Antioxidant

Article Details

How to Cite
1.
Paramitha S, Firdausi ASB, Fadilla S, Rahmah FS, Ar-Riziq MA, Rahmayanti M. Shallot (Allium cepa Lour) Peels Snack Bar as Immunomodulator for Health Improvement in the Digital Era. EKSAKTA [Internet]. 2022Dec.30 [cited 2024Jun.21];23(04):309-21. Available from: https://eksakta.ppj.unp.ac.id/index.php/eksakta/article/view/355

References

  1. Suyanto, S., Latifah, K., & Muchid, M. (2022). Transformation of Radio Technology in The Digital Age. Nyimak: Journal of Communication, 6(1), 115-130.
  2. Paskevice, A., & Pozeriene, J. (2020). Internationalism in a global space: what benefits are being felt?. Humanities studies, (6 (83)), 109-123.
  3. Nikolaeva, E. M., & Kotliar, P. S. (2021). Distributed cognitive activity as the basis of digital intellectual production: possibilities of hypertext interpretation. Laplage em Revista, 7(3D), 210-218.
  4. Jeličić, R. (2020). Digital alphabet–a challenge for the modern student and teacher. Metodički obzori: časopis za odgojno-obrazovnu teoriju i praksu, 15(2 (29)), 91-105.
  5. Amović, M., Vujović, V., & Milinković, S. (2020). The role and importance of Smart Systems concept in the Industry 4.0. International Journal of Electrical Engineering and Computing, 4(2), 101-110.
  6. Tilleczek, K. C., Bell, B. L., & Munro, M. (2019). Youth well-being and digital media. In Youth in the Digital Age (pp. 39-59). Routledge.
  7. Apdillah, D., Salam, A., Tania, I., & Lubis, L. K. A. (2022). Optimizing Communication Ethics in the Digital Age. Journal of Humanities, Social Sciences and Business (JHSSB), 1(3), 19-26.
  8. Horvath, A. (2022). Possessed by technology: The metastasis of absence. In The Technologisation of the Social (pp. 47-65). Routledge.
  9. Hassoun, D. (2019). Logics of Attention: Watching and Not-Watching Film and Television in Everyday Life (Doctoral dissertation, faculty of the University Graduate School in partial fulfillment of the requirements For the degree Doctor of Philosophy in the Department of Communication and Culture, Indiana University).
  10. Resvina, A. M., Widodo, C. S., & Naba, A. (2019). Study effect of electromagnetic wave exposure of radio frequency in blood cells for Interleukin-2 (Il-2) production peripheral culture blood mononuclear cells (PBMC). Int J Med Sci, 6, 15-8.
  11. Cao, X., Jie, Y., Ma, P., & Wang, Z. L. (2020). Wherever there is a dynamic touch, there is electromagnetic field——a discovery for power generation. Nano Energy, 78, 105314.
  12. Baba, A. M., Elizabeth, O. N., & Usman, A. U. (2022). Radio Frequency Energy Harvester For Wireless Sensor Nodes And Mobile Phone Batteries: A Review.
  13. Kour, H., & Jha, R. K. (2020). Em radiation reduction in wcn: Towards safe generations. In 2020 International Conference on COMmunication Systems & NETworkS (COMSNETS) (pp. 559-562). IEEE.
  14. Young, B., Cranwell, J., Fogarty, A. W., Skelly, R., Sturrock, N., Norwood, M., & Thurley, P. (2019). Evaluation of the impact of a brief educational message on clinicians’ awareness of risks of ionising-radiation exposure in imaging investigations: a pilot pre-post intervention study. BMC Health Services Research, 19(1), 1-7.
  15. Fukunaga, H., & Asano, T. (2022). A brief overview of the registration system of radiation exposure doses for decontamination workers and their occupational health management. Journal of Occupational Health, 64(1), e12357.
  16. Irfan, M. (2019). Review on Health Risks Associated With Mobile Phones Usage. European Journal of Molecular & Clinical Medicine, 7(06), 2020.
  17. Kim, J. H., Lee, J. K., Kim, H. G., Kim, K. B., & Kim, H. R. (2019). Possible effects of radiofrequency electromagnetic field exposure on central nerve system. Biomolecules & therapeutics, 27(3), 265.
  18. Jafer, A. M. (2021). In vivo long-term effects of radiation on gene expression (Doctoral dissertation, University of Leicester).
  19. Michaels, R. A. (2019). Telecommunications, Electromagnetic Fields, and Human Health. Environmental Claims Journal, 31(2), 93-132.
  20. Gavard, A. (2020). Neurodegenerative effects of radiofrequency fields (Doctoral dissertation, University of Oxford).
  21. Samarth, R., Kumar, M., Matsumoto, Y., & Manda, K. (2020). The Effects of Ionizing and Non-Ionizing Radiation on Health. Recent Trends and Advances in Environmental Health, 179.
  22. Joseph, R. P. (2019). Assess The Knowledge Regarding Mobile Hazards on Pregnant Women in Selected Hospital. Think India Journal, 22(17), 4587-4593.
  23. Shirbandi, K., Khalafi, M., Bevelacqua, J. J., Sadeghian, N., Adiban, S., Bahaeddini Zarandi, F., & Welsh, J. J. (2022). Exposure to Low Levels of Radiofrequency Electromagnetic Fields Emitted from Cell-phones as a Promising Treatment of Alzheimer’sDisease: A Scoping Review Study. Journal of Biomedical Physics and Engineering.
  24. Samarth, R., Kumar, M., Matsumoto, Y., & Manda, K. The Effects of Ionizing and Non-Ionizing Radiation on Health. Recent Trends and Advances in Environmental Health, 179.
  25. Narayanan, S. N., Jetti, R., Kesari, K. K., Kumar, R. S., Nayak, S. B., & Bhat, P. G. (2019). Radiofrequency electromagnetic radiation-induced behavioral changes and their possible basis. Environmental Science and Pollution Research, 26(30), 30693-30710.
  26. Balmori, A. (2022). Evidence for a health risk by RF on humans living around mobile phone base stations: From radiofrequency sickness to cancer. Environmental Research, 113851.
  27. Schandy, A. E., & Simini, F. (2020). Mobile phone radiation and brain cancer at the dawn of the 5G era: Student Article. Revista Argentina de Bioingeniería, 24(4), 21-24.
  28. Bartosova, K., Neruda, M., & Vojtech, L. (2021). Methodology of Studying Effects of Mobile Phone Radiation on Organisms: Technical Aspects. International Journal of Environmental Research and Public Health, 18(23), 12642.
  29. Palavy, V., & Safronava, A. (2020). The Influence of Office Environment on the Health of Workers.
  30. Sedani, B. S., Kotak, N. A., & Borisagar, K. R. (2021). Critical Review on Effect of 5G Technology on Covid-19 and Human Health Issues. Journal of Scientific Research, 13(2), 695-705.
  31. McKesey, J., & Fabi, S. G. (2022). Is the Technology Era Aging You? A Review of the Physiologic and Psychologic Toll of Technology Use. Dermatologic Surgery, 48(9), 978-988.
  32. Akakin, D., Tok, O. E., Anil, D., Akakin, A., Sirvanci, S., Sener, G., & Ercan, F. (2021). Electromagnetic waves from mobile phones may affect rat brain during development. Turk. Neurosurg, 31, 412-421.
  33. Mahboubi, A. (2022). The Side Effects of Electromagnetic Waves on the Human Brain: A review study. In 11th Majlesi Conference on Electrical Engineering.
  34. Shbanah, M., & Kovács, T. A. (2022). The Effects of Electromagnetic Waves on Human Health. In Security-Related Advanced Technologies in Critical Infrastructure Protection (pp. 161-167). Springer, Dordrecht.
  35. Movahedi, M. M., Tavakoli Golpayegani, A., Safari, A., & Amani, S. (2019). Effects of Short-term Exposure to Electromagnetic Fields Emitted by 3G and 4G Mobile Phones on Reaction Time and Short-term Memory. Iranian Journal of Medical Physics, 16(3), 250-254.
  36. Polak, E., Stępień, A. E., Gol, O., & Tabarkiewicz, J. (2021). Potential immunomodulatory effects from consumption of nutrients in whole foods and supplements on the frequency and course of infection: preliminary results. Nutrients, 13(4), 1157.
  37. Maheshwari, S., Kumar, V., Bhadauria, G., & Mishra, A. (2022). Immunomodulatory potential of phytochemicals and other bioactive compounds of fruits: A review. Food Frontiers.
  38. Oyedepo, T. A., Morakinyo, A. E., & Babarinde, S. O. (2022). Immune Boosting Activity of Nutraceuticals and Functional Foods. In Immunomodulators and Human Health (pp. 71-100). Springer, Singapore.
  39. Polak, E., Stępień, A. E., Gol, O., & Tabarkiewicz, J. (2021). Potential immunomodulatory effects from consumption of nutrients in whole foods and supplements on the frequency and course of infection: preliminary results. Nutrients, 13(4), 1157.
  40. Dhillon, N. K., & Ahuja, S. (2019). Plants as immunomodulators: A review. J. Pharmacogn. Phytochem, 8, 364-368.
  41. Oktari, K., Azizah, Z., Chandra, B., & Asra, R. (2020). A review: Antioxidant and immunomodulator effects of black garlic. EAS J Pharm Pharmacol, 2(6), 193-8.
  42. Parbat, A. Y., Malode, G. P., Shaikh, A. R., Panchale, W. A., Manwar, J. V., & Bakal, R. L. (2021). Ethnopharmacological review of traditional medicinal plants as immunomodulator. World Journal of Biology Pharmacy and Health Sciences, 6(2), 043-055.
  43. Chavan, H., Borate, A., Chaure, S., & Muley, S. S. (2020). General Overview on Immunomodulator Activity of Herbal Natural Products.
  44. Pertiwi, K. R., & Atun, S. (2022). Potential Indonesian Herbs to Develop a Mix Herbal Immunomodulator Supplement: A Hermeneutic Systematic Review. Journal of Drug and Alcohol Research, 11(1).
  45. Ibrahim, S. R., El-Halawany, A. M., El-Dine, R. S., Mohamed, G. A., & Abdallah, H. M. (2022). Middle Eastern Diets as a Potential Source of Immunomodulators. In Plants and Phytomolecules for Immunomodulation (pp. 163-190). Springer, Singapore.
  46. Batatinha, H. A., Biondo, L. A., Lira, F. S., Castell, L. M., & Rosa-Neto, J. C. (2019). Nutrients, immune system, and exercise: Where will it take us. Nutrition, 61, 151-156.
  47. Nakkala, J. R., Li, Z., Ahmad, W., Wang, K., & Gao, C. (2021). Immunomodulatory biomaterials and their application in therapies for chronic inflammation-related diseases. Acta Biomaterialia, 123, 1-30.
  48. Gururani, S., Gairola, K., & Dubey, S. K. (2022). Antioxidants and Immunomodulation. In Immunomodulators and Human Health (pp. 101-121). Springer, Singapore.
  49. Anitasari, R. F. (2019). Agrarian Law: Perspective of Indonesia Agricultural Policies. South East Asia Journal of Contemporary Business, Economic and Law, 20(4).
  50. Purwanti, E., Mahmudati, N., Faradila, S. F., & Fauzi, A. (2020). Utilization of plants as traditional medicine for various diseases: Ethnobotany study in Sumenep, Indonesia. In AIP Conference Proceedings (Vol. 2231, No. 1, p. 040024). AIP Publishing LLC.
  51. Jumiati, E., & Ismandari, T. (2022). The Potency of Karamunting Borneo Plants from Weeds Into Herbs. In IOP Conference Series: Earth and Environmental Science (Vol. 1083, No. 1, p. 012003). IOP Publishing.
  52. Harmen, H. (2020). Diversity of plants as food supplement and medicine for livestock: Local culture in cattleman communities. Asian Journal of Ethnobiology, 3(1).
  53. Nazarova, Z. M., Zabaikin, Y., & Kharlamov, M. (2022). Optimization of Technological Process Parameters to Create an Environmentally Friendly Waste Processing Technology. Ecological Engineering & Environmental Technology, 23(3), 15-22.
  54. Zaleski, P., & Chawla, Y. (2020). Circular economy in Poland: Profitability analysis for two methods of waste processing in small municipalities. Energies, 13(19), 5166.
  55. Żukiewicz, K., Dudziak, A., Słowik, T., Mazur, J., & Łusiak, P. (2022). Analysis of the Problem of Waste in Relation to Food Consumers. Sustainability, 14(18), 11126.
  56. Maryuni, D. R., Prameswari, D. A., Astari, S. D., Sari, S. P., & Putri, D. N. (2022). Identification Of Active Compounds In Red Onion (Allium Ascalonicum L.) Peel Extract By Lc-Esi-Qtof-Ms/Ms And Determination Of Its Antioxidant Activity. Jurnal Teknologi Hasil Pertanian, 15(1), 20-33.
  57. Bhosale, Y. K., Varghese, S. M., Thivya, P., Hema, V., & Sinija, V. R. (2021). Studies on assessment of safety and nutritional quality of shallot waste fractions. Journal of Food Processing and Preservation, 45(2), e15147.
  58. Khasherao, B. Y., Hema, V., & Sinija, V. R. (2021). Effect of shallot waste (Allium cepa L. var. aggregatum) and their extracts on quality of developed pasta.
  59. Agustin, A. D., Purwasih, R., & Fadilla, F. (2021). Quality Test and Determination Flavonoid Content of Crackers Shallot (Allium CepaL.) Peel Flour. Jurnal Kebidanan dan Kesehatan Tradisional, 31-40.
  60. Bhosale, Y. K., Varghese, S. M., Thivya, P., Hema, V., & Sinija, V. R. (2021). Studies on assessment of safety and nutritional quality of shallot waste fractions. Journal of Food Processing and Preservation, 45(2), e15147.
  61. Moldovan, C., Frumuzachi, O., Babotă, M., Barros, L., Mocan, A., Carradori, S., & Crişan, G. (2022). Therapeutic Uses and Pharmacological Properties of Shallot (Allium ascalonicum): A Systematic Review. Frontiers in Nutrition, 9.
  62. Adusei, S., Otchere, J. K., Oteng, P., Mensah, R. Q., & Tei-Mensah, E. (2019). Phytochemical analysis, antioxidant and metal chelating capacity of Tetrapleura tetraptera. Heliyon, 5(11), e02762.
  63. Zahara, K., Ahmad, N., Bibi, Y., Bibi, F., Sadaf, H. M., & Sardar, N. (2019). An insight to therapeutic potential and phytochemical profile of Solanum villosum (L). Medicine in Drug Discovery, 2, 100007.
  64. Hasan, K., Sabiha, S., & Hoque, Z. (2022). Qualitative analysis of some phytochemical constituents and antimicrobial tests of Helotropium supinum L. medicinal plant. GSC Biological and Pharmaceutical Sciences, 19(2), 057-063.
  65. Wijayanti, S. I. (202). Food Nutrition Test For Fullday Class Students Through Lesson Study At Mts Muhammadiyah Batang. In Prosiding Seminar Nasional & Internasional.
  66. Aminullah, A., Marwiyah, S. W., & Kusumaningrum, I. (2021). Application of Catfish Flour on Texture and Hedonic Profiles Of Pempek Lenjer. Agrointek.
  67. Utari, A., & Warly, L. (2021). Tannin Contents of Jackfruit Leaves (Artocarpus heterophyllus) extract and Moringa Leaves (Moringa oleifera) extract as Functional Additive Feed in Ruminan Livestock. In IOP Conference Series: Earth and Environmental Science (Vol. 757, No. 1, p. 012054). IOP Publishing.
  68. Sari, D. P., & Wulandari, R. L. (2022). Anti-inflammatory effects of Ethanol Extract of Cymbopogon nardus Herb on Rats Induced by Carrageenan. In Proceeding of Mandala Waluya International Conference on Pharmaceutical Science and Practice (Vol. 1, No. 1, pp. 16-23).
  69. Kumar, N., Singh, H., & Sharma, S. K. (2020). Antioxidants: responses and importance in plant defense system. In Sustainable Agriculture in the Era of Climate Change (pp. 251-264). Springer, Cham.
  70. Adeleke, B. S., & Babalola, O. O. (2020). Oilseed crop sunflower (Helianthus annuus) as a source of food: Nutritional and health benefits. Food Science & Nutrition, 8(9), 4666-4684.
  71. Parcheta, M., Świsłocka, R., Orzechowska, S., Akimowicz, M., Choińska, R., & Lewandowski, W. (2021). Recent developments in effective antioxidants: The structure and antioxidant properties. Materials, 14(8), 1984.
  72. Hikmawanti, N. P. E., Fatmawati, S., & Asri, A. W. (2021). The effect of ethanol concentrations as the extraction solvent on antioxidant activity of Katuk (Sauropus androgynus (L.) Merr.) leaves extracts. In IOP Conference Series: Earth and Environmental Science (Vol. 755, No. 1, p. 012060). IOP Publishing.
  73. Haerani, A., Chaerunisa, A. Y., & Subarnas, A. (2019). Antioxidant Activities of Muntingia calabura, Syzygium cumini, Ocimum basilicum, and Eleutherine bulbosa using DPPH Method. Indones J Pharm, 1(2), 57-61.
  74. Hasmila, I., Natsir, H., & Soekamto, N. H. (2019). Phytochemical analysis and antioxidant activity of soursop leaf extract (Annona muricata Linn.). In Journal of Physics: Conference Series (Vol. 1341, No. 3, p. 032027)
  75. Rahayu, T. D., Ardana, M., & Rijai, L. (2017). Potensi Kulit Bawang Merah (Allium Cepa L) Sebagai Antoksidan Dan Tabir Surya. In Proceeding of Mulawarman Pharmaceuticals Conferences (Vol. 6, pp. 84-89).
  76. Umami, N., & Agus, A. (2022). Stingless bee honey (Tetragonula laeviceps): Chemical composition and their potential roles as an immunomodulator in malnourished rats. Saudi Journal of Biological Sciences, 29(10), 103404.
  77. Benvenuto, M., Focaccetti, C., Ciuffa, S., Fazi, S., Bei, A., Miele, M. T., & Bei, R. (2021). Polyphenols affect the humoral response in cancer, infectious and allergic diseases and autoimmunity by modulating the activity of TH1 and TH2 cells. Current Opinion in Pharmacology, 60, 315-330.
  78. Munhoz, J., Peron, G., Bonfanti, A. P., Oliveira, J., da Rocha‐e‐Silva, T. A., Sutti, R., ... & Rapôso, C. (2021). Components from spider venom activate macrophages against glioblastoma cells: new potential adjuvants for anticancer immunotherapy. The Journal of Biochemistry, 170(1), 51-68.
  79. Gonzalez, P. J., & Sörensen, P. M. (2020). Characterization of saponin foam from Saponaria officinalis for food applications. Food Hydrocolloids, 101, 105541.
  80. Sarath, P. (2019). A comparative evaluation of phytochemicals in bark, leaves and seeds of Putranjiva roxburghii Wall (Putranjivaceae). Journal of Pharmacognosy and phytochemistry, 8(1), 1162-1166.
  81. Rahmatan, H., & Andesa, S. K. (2021). Effect of drying and composition ratio of herbal tea prepared from Clitoria ternatea L. and Ocimum sanctum L. on its antioxidant capacity. In Journal of Physics: Conference Series (Vol. 1940, No. 1, p. 012060).
  82. Mazaya, G., Karseno, K., & Yanto, T. (2020). Antimicrobial and phytochemical activity of coconut shell extracts. Turkish Journal of Agriculture-Food Science and Technology, 8(5), 1090-1097.
  83. Hamzah, B., Rahmawati, S., Suwena, W. S., Hardani, M. F., & Hardani, R. (2020). Analysis of Tannin in Sapodilla Fruit (Manilkara Zapota (L) Van Royen). Rasayan Journal of Chemistry, 13(04), 2243-2248.