Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464) 2021-03-03T18:59:36+00:00 Dr Rahadian Zainul M,Si (SCOPUS Author ID: 56737195700) Open Journal Systems <p><strong>Eksakta : Berkala Ilmiah Bidang MIPA <a href="">(</a><a href=";1487060477&amp;1&amp;&amp;">E-ISSN : 2549-7464) </a></strong>is an open access journal and peer-reviewed that publishes either original articles or reviews. This journal is published by <strong>Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia.</strong> The journal is dedicated towards dissemination of knowledge related to the advancement in scientific research. The prestigious interdisciplinary editorial board reflects the diversity of subjects covered in this journal. Under the realm of science and technology, the coverage includes environmental science, pure and applied mathematics, agricultural research and engineering, biology, biotechnology, bioinformatics, Healthcare sciences (including clinical medicine, preventive medicine &amp; public health), physics, biophysics, computer science, chemistry and bioengineering, to name a few. Since 2017 (Volume 19) <strong>Eksakta : Berkala Ilmiah Bidang MIPA</strong> <a href=";1487060477&amp;1&amp;&amp;"><strong>(E-ISSN : 2549-7464) </strong></a>publish two issues (numbers) annually (<strong>April</strong> and <strong>October</strong>). <strong>On 9<sup>th</sup> October, 2020</strong>, the <strong><em>frequency of journal publications</em></strong> changed through the<strong> ISSN LIPI decree</strong>. The ISSN LIPI letter stated that starting <strong>in 2021</strong>, our journal will <strong>publish 4 issues in a year</strong>, namely <strong>January</strong>, <strong>April</strong>, <strong>July</strong> and <strong>October</strong>. The <strong>first issue (No 1)</strong> is published<strong> every 30 January</strong>, the <strong>second issue (No 2)</strong> is published <strong>every 30 April</strong>, the <strong>third issue (No 3)</strong> is published <strong>every 30 July</strong>, and the <strong>fourth issue (No 4)</strong> will be published <strong>every 30 October</strong>. </p> The Modeling and Simulation Longitudinal Mobile Robotic For Planetary Exploration in Rough Terrain 2021-03-03T18:59:36+00:00 Emilliano Emilliano <p>Model mobile robot that used to this simulation is type car like vehicle steering. Mobile robot type car like vehicle steering is mobile robot that move using force of rear wheel and front rear of mobile robot functions as steering to control direction of mobile robot. The dynamic nonlinear model mobile robot is implemented to view influence disturbance of mobile robot to longitudinal direction mobile robot that used to planetary exploration in rough terrain. The model that used to simulation is nonlinear multivariable MIMO with 5 input and 7 output. The simulation has done by using Simulink of Matlab. The simulations were carried out by giving 4 conditions, namely without disturbance, with an incline angle of 30 (0.5236 rad), with a rough terrain angle of 28.6479 (+0.5 rad), and a combination of 30 incline angle and 28.6479 rough terrain angle. The simulation results with 3 mobile robots show accurate results.</p> Copyright (c) Potential Hydrophobic Pocket of Squalene Synthase: An In Silico Analysis 2021-02-25T16:55:32+00:00 Fitri Amelia <p>Cardiovascular disease cases increase due to consumption cholesterol dietary habit. It is well-known that squalence synthase (SQS) is the first committed enzyme for cholesterol synthesis. Therefore, SQS become target of anti-cholesterol. This paper aims to determine the potential binding pocket of SQS (PDB ID: 1EZF). Dogsitescorer, siteFinder, and DEPTH were used for binding pocket prediction and MOE 2009.10 was performed for molecular docking. We found that there are five out of 37 pockets which have druggability score above 0.8. Pocket_5 is the highest drugability and favorable for hydrophobic interaction, yet lower number of hydrogen bond with the ligand. However, Pocket_2, and Pocket_3 are suitable for hydrogen bond formation of ligand-protein. Molecular docking study showed that TAK-475, D99, and Cynarin inhibitors were embedded on the P_2 and P_3 of SQS, showing that P2_and P3 are promising binding pocket for ligand interactions. These results show a promising alternative to design anti-cholesterol using these potential pocket in silico.</p> Copyright (c)